285 INHIBITION OF THROMBIN MEDIATED PLATELET AGGREGATION BY UTEROGLOBIN
نویسندگان
چکیده
منابع مشابه
Adenosine - mediated Inhibition of Platelet Aggregation by Acadesine A
Inhibition of platelet aggregation by acadesine was evaluated both in vitro and ex vivo in human whole blood using impedance aggregometry, as well as in vivo in a canine model of platelet-dependent cyclic coronary flow reductions. In vitro, incubation of acadesine in whole blood inhibited ADP-induced platelet aggregation by 50% at 240±60 ,IM. Inhibition of platelet aggregation was time dependen...
متن کاملAdenosine - mediated Inhibition of Platelet Aggregation by Acadesine
Inhibition of platelet aggregation by acadesine was evaluated both in vitro and ex vivo in human whole blood using impedance aggregometry, as well as in vivo in a canine model of platelet-dependent cyclic coronary flow reductions. In vitro, incubation of acadesine in whole blood inhibited ADP-induced platelet aggregation by 50% at 240±60 ,IM. Inhibition of platelet aggregation was time dependen...
متن کاملInhibition of platelet aggregation by rat trophoblasts.
OBJECTIVE To determine the effect of rat trophoblast cell suspensions on adenosine diphosphate (ADP)-induced platelet aggregation. MATERIALS AND METHODS The trophoblasts were isolated from ectoplacental cones (a preplacental tissue very rich in trophoblasts) developed in rat embryos on day 12 of pregnancy (normal period of gestation: 22-23 days). Platelet-rich plasma (PRP) was obtained from a...
متن کاملStructure-function relations in platelet-thrombin reactions. Inhibition of platelet-thrombin interactions by lysine modification.
The chemical modification of lysine residues in human alpha-thrombin has been used to study the interaction of thrombin with human platelets. Phosphopyridoxylation of thrombin using pyridoxal 5'-phosphate (pyridoxal-P) has been shown to inhibit the fibrinogen clotting activity of thrombin but not the catalytic activity (Griffith, M. J. J. Biol. Chem. 254, 3401-3406). Phosphopyridoxylation resul...
متن کاملPrevention of platelet-rich arterial thrombosis by selective thrombin inhibition.
The effect of heparin and of the synthetic competitive thrombin inhibitor (2R,4R)-4-methyl-1-[N2-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfon yl)-L-arginyl]-2-piperidinecarboxylic acid monohydrate (argatroban) on platelet-rich arterial thrombosis was studied in a rabbit model, consisting of a 4-6-mm everted ("inside-out") femoral arterial segment. Intravenous injection of heparin (200 units/k...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198504000-00315